Characterization of P2x-receptors in rabbit isolated ear artery
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چکیده
منابع مشابه
Pharmacological characterization of the "silent" 5-hydroxytryptamine1B-like receptors of rabbit ear artery.
Serotonin acts on 5-hydroxytryptamine (5-HT)1B-like receptors in isolated rabbit ear artery precontracted with phenylephrine (PHE). These receptors are inactive, or "silent," in untreated vessels. Ear artery rings were mounted in tissue baths for the measurement of isometric contraction to further characterize these 5-HT1B-like receptors. The 5-HT1-selective receptor agonist sumatriptan failed ...
متن کاملBiphasic vasoconstriction of the rabbit ear artery.
Sympathetic nerve stimulation and intralummal norepinephrine infusion for more than 15 seconds produced a biphasic response in the isolated rabbit ear artery perfused with RREBS solution. This response consisted of an initial rapid constriction (phase A), which was followed by partial relaxation, and a final slowly developing constriction (phase B), which lasted for the duration of nerve stimul...
متن کاملP2X receptors.
Extracellular adenosine 5'-triphosphate (ATP) activates cell surface P2X and P2Y receptors. P2X receptors are membrane ion channels preferably permeable to sodium, potassium and calcium that open within milliseconds of the binding of ATP. In molecular architecture, they form a unique structural family. The receptor is a trimer, the binding of ATP between subunits causes them to flex together wi...
متن کاملIdentification of alpha-1L adrenoceptor in rabbit ear artery.
The alpha-1L adrenoceptor (AR) was identified in rabbit ear artery by both functional and ligand binding studies. In functional studies using arterial rings, the contractile response to NS-49 [(R)-(-)-3'-(2-amino-1-hydroxyethyl)-4'-fluorometh-anesulfonanilide hydrochloride] (alpha-1A and alpha-1L AR-selective agonist) was competitively antagonized with low affinities by prazosin, RS-17053 [N-[2...
متن کاملMolecular and functional characterization of human P2X(2) receptors.
P2X receptors are a family of ATP-gated ion channels. Four cDNAs with a high degree of homology to the rat P2X(2) receptor were isolated from human pituitary and pancreas RNA. Genomic sequence indicated that these cDNAs represent alternatively spliced messages. Northern analysis revealed high levels of human P2X(2) (hP2X(2)) message in the pancreas, and splice variants could be detected in a va...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1990
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1990.tb14133.x